Modelling Biological Age: From Epigenetic Clocks to Stem Cell Dynamics
Speaker: Eric Latorre Crespo (CRM)
Date: 16/01/2025
Time: 10:00 CEST
Host: Nora Martin (CRG)
DNA methylation changes have emerged as powerful biomarkers of biological aging, yet the underlying mechanisms driving these epigenetic alterations remain incompletely understood. In this talk I will review the rise of epigenetic clocks as biomarkers of biological age and motivate the need for a mathematical description of methylation changes to accurately translate insights from epigenetic clocks into a biological framework. I will show how a parsimonious Markovian model of methylation dynamics successfully leverages age-related methylation changes to uncover mechanisms of longevity across mammalian species and within human populations, suggesting stem cell dynamics as a fundamental driver of aging.
If you would like to attend the seminar, please register here.