Gene editing is revolutionizing bioscience and therapy. Our lab has developed a gene writing tool combining the precision of CRISPR and gene transfer capacity of a transposase (Pallarès-Masmitjà et al, Nat Com 2021). We are planning to develop improved gene writers for safer and more efficient therapies with aid of the B-bio (new retrovirus-based directed evolution platform developed by our lab (Ivancic et al, in preparation). A key part for the success of this massively genotype testing platform is library design and analysis using AI. Large language models are being very powerful to represent protein language and will be used to fuel genotypes and accelerate evolution. Coupling this biological hardware with AI is generating a fascinating synergy for enhancing the evolutionary rate of new CRISPR based editors and writers.

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